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Modelling IL-6 mediated ADME gene regulation
Published on Jul 21, 20141459 Views
Questions\\ Cytokines, such as IL-6, are produced during inflammation and act on hepatocytes to initiate the acute phase response. This results in broad influence on the detoxification capacity of t
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Modelling IL-6 mediated ADME gene regulation00:00
Impact of inflammation on drug clearance00:25
Experimental design and workflow00:56
IL-6-induced changes in gene expression01:42
Topological model with relevant pathways02:43
Western Blot after IL-6 stimulation03:22
Chemical Inhibition of major signaling pathways 03:36
Fuzzy logic modelling 04:00
Optimization process: CNORfuzzy04:55
Creating the IL-6 model 06:14
Optimized model family 07:04
Fitting results 07:52
Model-derived hypotheses 08:38
Summary09:28
Thank you!09:49