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PK-Sim 5 for Physiology Based PK modelling: Introduction and Demonstration

Published on Jul 21, 20144243 Views

Tobias Kanacher

Physiology-based pharmacokinetic models (PBPK) describe adsorption, distribution, metabolisation and excretion of drugs in the human body based on a large amount of prior physiological knowledge. Sp

MDO 2014 - Stuttgart

Related categories

Medicine

Chapter list

PK-Sim 5 for Physiology Based PK modelling00:00
Definition of PBPK Modelling02:15
Early PBPK modelling - 103:33
Early PBPK modelling - 204:22
Early PBPK modelling - 305:26
Early PBPK modelling - 405:40
Early PBPK modelling - 506:06
Correlating in vitro data with in vivo PK - 106:25
Correlating in vitro data with in vivo PK - 208:21
Parameters of a PBPK Model09:13
PBPK Challenge & Opportunity - 111:29
PBPK Challenge & Opportunity - 211:47
PBPK Challenge & Opportunity - 313:22
Position of Regulatory Agencies (FDA)14:17
Regulatory submissions with PBPK Data (provided by FDA)15:30
Main Area ofApplication: Special Populations16:16
The BTS Software Platform19:53
BTS Systems Biology Software Suite: Multiscale Mechanistic Modeling21:34
PK-Sim for academic Users22:14
New Software Platform with PK-Sim 5 and MoBi 3 - 123:45
New Software Platform with PK-Sim 5 and MoBi 3 - 226:00
New Software Platform with PK-Sim 5 and MoBi 3 - 326:01
New Software Platform with PK-Sim 5 and MoBi 3 - 426:02
New Software Platform with PK-Sim 5 and MoBi 3 - 526:02
New Software Platform with PK-Sim 5 and MoBi 3 - 626:02
New Software Platform with PK-Sim 5 and MoBi 3 - 726:03
New Software Platform with PK-Sim 5 and MoBi 3 - 826:03
PK-Sim Model structure26:04
A New Compartmental Gastro-Intestinal Transit Model28:05
Integration of Expression Data30:05
History and Rollback function32:18
The PK-Sim Building Block Concept33:50
PK-Sim: Workflow – Quick Guide 135:40
PK-Sim: Workflow – Quick Guide 236:07
PK-Sim: Workflow – Quick Guide 337:14
PK-Sim: Workflow – Quick Guide 437:18
PK-Sim: Workflow – Quick Guide 537:51
PK-Sim: Workflow – Quick Guide 638:36
Demo: Insertion Of An Active Transport39:36
PK-Sim®: Sub-structure of the PBPK Model - 141:11
PK-Sim®: Sub-structure of the PBPK Model - 241:58
PK-Sim®: Distribution - 142:30
PK-Sim®: Distribution - 243:32
Understanding PK – Need for a transporter44:20
Demo46:00