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Feedback mechanisms and systems medicine: Modeling cholesterol homeostasis for drug discovery
Published on Jul 21, 20142105 Views
Feedback mechanisms are the key features of cellular organisation; however, they can cause severe misinterpretation of the data. Cholesterol biosynthesis is a robust and highly regulated pathway; ne
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Chapter list
Feedback mechanisms and systems medicine: Modelling cholesterol homeostasis for drug discovery00:00
Object Oriented Modelling - Translation From Machinery To Biomedicine - 100:05
Object Oriented Modelling - Translation From Machinery To Biomedicine - 201:00
What will we model?01:36
Why?02:30
Potential targets for cholesterol lowering drugs02:33
Statins - 103:10
Statins - 203:15
SYSBIO library specifications03:42
Expert-based simplified mathematical model of cholesterol biosynthesis05:23
Mathematical background06:08
Basic concept06:31
Hands-on tutorial07:10
Smith–Lemli–Opitzsyndrome (SLOS)40:55
Model predicts novel branches from the cholesterol synthesis pathway45:20