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Vloga medicinske fizike v času natančne medicine
Published on Jul 04, 2018596 Views
Medicinska fizika je tesno povezana z medicino; zato se tudi razvija v podobni smeri. Ključni trend v medicini, predvsem onkologiji, je usmerjen v personalizacijo zdravljenja. Natančnejše profiliranje
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Chapter list
Role of Medical Physics in the Era of Precision Medicine00:00
PRECISION MEDICINE00:36
Future of medicine00:55
Ten years later…01:59
What is precision medicine?03:46
Precision medicine (example)05:05
How do we assess tumor biology?06:53
Have you noticed HETEROGENEITY?08:53
The problem of tumor BIOPSY…08:58
Tumors are heterogeneous…09:30
…and they are heterogeneous a lot!10:10
Tumors are evolving…10:58
…and they are evolving a lot!11:28
Heterogeneity + Evolution = Resistance13:05
Qualitative vs Quantitative Imaging13:47
How much variability is there? - 116:52
How much variability is there? - 217:51
What should we do? - 118:44
What should we do? - 219:13
Qualitative imaging chain - 119:54
Qualitative imaging chain - 221:14
Role of medical physics21:30
How this impacts clinical decisions? - 122:40
How this impacts clinical decisions? - 223:20
TUMOR HETEROGENEITY AND RESISTANCE23:55
Let’s look at the metastatic disease24:07
How can molecular imaging help?25:13
Repeatability of NaF PET/CT26:20
What is our quantitative accuracy? - 127:45
What is our quantitative accuracy? - 227:55
Quantitative Total Bone Imaging (QTBI) - 128:58
Quantitative Total Bone Imaging (QTBI) - 230:05
How much is repeatability?30:48
Limits of agreement define response32:07
Imaging site affects repeatibility32:27
Lesion location affects repeatability 32:34
WHAT INFORMATION CAN WE EXTRACT FROM IMAGING?33:17
Does this make an impact?33:26
Global correlation to PFS33:52
Mid-Tx functional burden34:57
Local disease heterogeneity - 135:53
Local disease heterogeneity - 236:55
Local disease heterogeneity - 337:40
Sample patient - 138:53
Sample patient - 239:43
“Oligo-resistance”40:09
Evolution of resistance41:55
Bridging the gap…43:00
Summary44:08
More information45:44
Thanks to... and questions46:26