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Macroevolution: The roots of good and evil go deep in time
Published on Feb 03, 20153096 Views
Although the molecular nature of tumours is well studied in vertebrates, their evolutionary origin remains unknown. In particular, there is no evidence for naturally occurring tumours in pre-bilateria
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Chapter list
Macroevolution00:00
Three stories00:24
Article01:22
The signing of the National Cancer Act of 197102:11
Diminishing Returns of Cancer Research02:46
1 Still dangerous03:53
National Cancer Institute04:31
Cancer05:27
Macroevolutionary origin of cancer - 106:12
Macroevolutionary origin of cancer - 207:08
Couldall animals develop tumors?07:33
...literature is not very informative07:48
Literature08:23
H. ogliactis - 109:14
H. ogliactis - 210:02
H. ogliactis - 310:21
Nanos11:50
Global expression divergence12:10
Tumorcells to invade at increased rates13:25
Differentiation arrest14:49
Model15:45
Are Hydratumors a disease?16:31
Microscopic View18:28
Conclusions –bona fidetumors in cnidarians - 119:01
Conclusions –bona fidetumors in cnidarians - 219:08
Conclusions - 119:55
Conclusions - 220:25
Conclusions - 320:53
Phylostratigraphic profiles in zebrafish uncover chordate origins of the vertebrate brain21:59
Vertebrate head22:37
Origin of the vertebrate brain? - 123:26
Origin of the vertebrate brain? - 224:06
Origin of the vertebrate brain? - 324:26
Origin of the vertebrate brain? - 424:58
Origin of the vertebrate brain? - 525:22
Genomic phylostratigraphy - 126:18
Genomic phylostratigraphy - 226:59
Genomic phylostratigraphy - 327:02
Hypothetical phylostratigraphic map - 127:08
Hypothetical phylostratigraphic map - 227:36
Statistics on the map28:27
Phylostrat software - 128:30
Phylostrat software - 228:59
Phylostrat software - 329:12
Phylostrat software - 429:34
Forebrain29:48
Pallium(cerebral cortex) - 129:59
Pallium(cerebral cortex) - 230:18
The adaptive landscape of the zebrafishCNS30:43
Conclusion - 131:12
Conclusion - 231:21
Parker 2003 -Light switch theory32:02