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Serum microRNA-profiles indicate a role of Fragile-X-related proteins for ALS
Published on Jul 21, 2017746 Views
In previous studies we identified a subset of downregulated serum microRNAs (miRNAs) in familial and a majority (~60%) of sporadic ALS patients that was already evident in pre-clinical mutation carr
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Serum microRNA-profiles indicate a role of Fragile-X-related proteins for ALS00:00
Previous studies: microarray analysis of extracelluar serum miRNAs in ALS00:07
Identification of proteins associated with the GDCGG-motif - 102:00
Identification of proteins associated with the GDCGG-motif - 203:03
Validation of candidate proteins: FXR1 directly interacts with GDCGG-miRNAs - 104:32
Validation of candidate proteins: FXR1 directly interacts with GDCGG-miRNAs - 206:11
FXR1, FXR2 and FMR1 directly bind to GDCGG-miRNAs via its RGG/RG-motifs06:58
FXR1 may be the most important player in ALS08:09
Summary and outlook10:17
Thank you!11:13