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Models for Protein-Protein Interaction Networks: What Do Age and (Large) Degree Tell Us?

Published on Jul 02, 20124282 Views

Gesine Reinert

Function Prediction in Complex Networks 2012 - Kavli Royal Society Centre

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Network AnalysisStatistics

Chapter list

Models for protein-protein interaction networks: what do age and (large) degree tell us?00:00
Outline00:03
Proteins00:23
Interaction detection01:19
Available datasets02:37
Predicting interactions03:12
Rosetta Stone/ Gene Fusion03:52
Phylogenetic profile04:07
Protein interaction networks04:54
A typical hairball picture06:17
Models for PINs06:47
GDDA and Threshold behaviour07:38
Issues with GDDA09:51
Why near threshold10:46
Comparison to other models11:20
Histograms12:19
No model fits13:59
How do age and high degree come into play?15:26
Protein age16:17
Protein age distribution in yeast17:07
Protein age and degree17:38
Protein age distribution: edges18:07
Protein age distribution: triangles19:03
Ego-network with protein ages highlighted19:42
What we see20:59
What we don’t see21:42
Conclusions22:18