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Protocell autonomy: linking processes through self-made boundaries / ‘Avtonomija protocelic’: povezovanje procesov s samoustvarjanjem meja
Published on Oct 21, 20113782 Views
Autonomy does not mean independence. It refers, rather, to the capacity of a system to define its own rules of operation as such a system, including the rules of interaction with its environment. T
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Chapter list
Protocell autonomy: linking processes through self-made boundaries00:00
Universal biochemical features05:45
Life08:55
Origins of life12:51
Laga15:38
Universal biophysical/biochemical features - 118:26
Universal biophysical/biochemical features - 220:17
From molecular to modular cell biology21:25
Main ‘bottom-up’ question: beyond (chemical) ‘self-organization22:10
... and ‘self-assembly’?23:44
Self-organization <-> Self-assembly - 124:39
Self-organization <-> Self-assembly - 225:22
‘Bottom-up’ approach self-organization self-assembly27:17
The first living systems27:43
Self-organization <-> Self-assembly - 328:36
‘Autopoietic vesicles’ (Pier Luigi Luisi)28:44
The emergence of competition between model protocells29:11
Minimal cell models30:18
‘Empty cell’ dynamics30:47
Reproducing real experimental data: swollen vs. deflated protocell competition dynamics30:47
A ‘proliferating microsphere’?30:49
Two-lipid membranes - 131:37
Two-lipid membranes - 231:39
Physical effects underlying the transitions from primitive to modern cell membranes31:39
Template-directed synthesis of a genetic in a model protocell31:40
Summary of experiments31:41
Bottom-up aproach: minimal ‘lipid-peptide’ cell31:42
Development of lipidic compartments <-> Production of molec. complexity (e.g., polypeptides)31:43
Modelling minimal self-(re-)producing ‘lipid-peptide’ cells31:43
Feedback mechanism: ‘self-regulation’ of waste release/transport33:16
Chiang et al. 200334:08
Lipid Bilayers34:44
Question: ‘reliable reproduction’ in protocells without templates or a complex metabolism ???35:04
General condition for the steady state cycle35:15
Final remarks35:27
(...at the collective level, this is not a sudden nor simple transition, either...)36:20
Thank you!37:45