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Energetics of the open - closed transition in the RYR N-terminal region: importance for the CPVT phenotype
Published on Jul 09, 2018418 Views
The central helix of the N-terminal region (NTR) of human cardiac ryanodine receptor (RyR) was shown to be crucial for NTR stability (1). Mutations in this helix were shown to cause the hereditary arr
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Chapter list
Energetics of the open - closed transition in the RyR N-terminal region: importance for the CPVT phenotype00:00
Excitation-contraction coupling - 100:41
Excitation-contraction coupling - 201:04
Excitation-contraction coupling - 301:28
Excitation-contraction coupling - 401:28
Excitation-contraction coupling - 501:48
Excitation-contraction coupling - 601:59
Excitation-contraction coupling - 702:35
Excitation-contraction coupling - 802:49
Excitation-contraction coupling - 902:50
Excitation-contraction coupling - 1002:52
Diastolic calcium release & arrhythmia - 103:14
Diastolic calcium release & arrhythmia - 204:27
Diastolic calcium release & arrhythmia - 304:35
Diastolic calcium release & arrhythmia - 404:40
Diastolic calcium release & arrhythmia - 505:08
Diastolic calcium release & arrhythmia - 605:40
Diastolic calcium release & arrhythmia - 705:49
Diastolic calcium release & arrhythmia - 806:35
Large-scale movements upon opening - 107:01
Large-scale movements upon opening - 207:03
Large-scale movements upon opening - 307:05
Large-scale movements upon opening - 407:07
Large-scale movements upon opening - 507:46
Large-scale movements upon opening - 607:56
Large-scale movements upon opening - 707:58
Large-scale movements upon opening - 808:00
Large-scale movements upon opening - 908:10
Large-scale movements upon opening - 1008:17
Large-scale movements upon opening - 1108:19
Large-scale movements upon opening - 1208:21
Large-scale movements upon opening - 1308:56
Large-scale movements upon opening - 1408:58
Large-scale movements upon opening - 1509:00
Large-scale movements upon opening - 1609:01
RyR2 activation by DP - 109:05
RyR2 activation by DP - 209:42
RyR2 activation by DP - 309:51
Construction of models - 110:16
Construction of models - 210:35
Construction of models - 310:47
Construction of models - 411:03
Construction of models - 511:12
Comparison of complex and mutants - 111:22
Comparison of complex and mutants - 211:50
Comparison of complex and mutants - 312:11
Comparison of complex and mutants - 412:40
Comparison of complex and mutants - 513:13
Comparison of complex and mutants - 613:26
Comparison of complex and mutants - 714:04
Comparison of complex and mutants - 814:19
Comparison of complex and mutants - 914:32
Conclusion - 114:58
Conclusion - 215:20
Conclusion - 315:25
Conclusion - 415:35
Acknowledgment - 116:18
Acknowledgment - 216:25