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Altered sleep oscillations as early biomarkers of Parkinson’s disease cholinopathy
Published on Jul 09, 2018391 Views
Rhythmic oscillations in the electroencephalographic (EEG) local field potentials underlie the basis of behavioral states and neurological diseases through coherent binding of the cooperating neuronal
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Chapter list
ALTERED SLEEP OSCILLATIONS AS EARLY BIOMARKERS OF PARKINSON’S DISEASE CHOLINOPATHY00:00
Definition of sleep ??00:37
• Our knowledge of the neural substrates of sleep is based on animal studies, primarily involving cat and rat02:19
WAKE, NREM, REM02:42
What are the sleep functions?03:48
Electrophysiological background04:00
FLIP-FLOP CONTROL OF REM SLEEP05:17
SLEEP and DEVELOPMENT05:59
Daily changes in sleep-wake state over lifetime - 106:44
Daily changes in sleep-wake state over lifetime - 207:12
REM sleep drive early in development is more related to high levels of electrical coupling then to changes in chemical transmission providing persistence of high frequency rhythms essential for waking08:34
Neurotransmitter systems in promoting wakefulness08:58
Neurotransmitter systems in promoting sleep09:52
Levels of sleep organization10:56
Thalamocortical generation of oscillatory rhythms of NREM11:10
Brain state dependent differences of cortical neuronal (pyramidal neurons) firing patterns12:24
Impact of brain state on the population distribution of neuronal firing rates13:08
97% RBD cases are α-synucleinopathy –14:10
Parkinson’s disease15:01
Parkinson’s disease at cellular level15:33
PPT as the higher relay nucleus in control of the integrated brain cholinergic function 16:10
Untitled16:21
Material and Methods Excitotoxic lesion (IBO lesion) 16:43
Material and Methods - Operative procedure 17:17
Material and Methods Sleep recording 6 h18:05
NADPH–diaphorase histochemical verification of the PPT lesion18:39
Topography of the cholinergic neuronal loss across aging19:44
NREM EEG microstructure in PPT lesion vs. control - 120:15
NREM EEG microstructure in PPT lesion vs. control - 221:28
Topography of the Wake/NREM/REM differentiation REM without atonia (RBD) in bi-PPT lesion ?21:39
Topography of the NREM EEG microstructure (NB vs. PPT lesion) - 123:31
Topography of the NREM EEG microstructure (NB vs. PPT lesion) - 223:58
Topography of the REM sleep alterations following the PPT lesion24:14
EEG microstructures during REM/REM1/REM2 states25:09
REM/REM1/REM2 coherence spectra25:41
Cortico-muscular coherence (CMC) - 126:26
Cortico-muscular coherence (CMC) - 226:50
Sleep architecture within the motor cortex (MCx) during aging27:02
Topography of ageing altered REM EEG microstructure27:29
Individual examples of the MCx REM spectrograms with their typical 10 s analog EEG signals throughout the overall ageing follow-up period in the control vs. PPT lesioned rat27:54
REM “enriched with” sigma oscillations in MCx28:26
Sleep spindles (SS) during REM “enriched” with sigma oscillatios29:01
Sleep spindle dynamics (density, duration, intrinsic frequency)29:34
Distinct MCx and Hipp sleep during PD cholinopathy30:03
Quantification of the PPT cholinergic neuronal loss30:27
Quantification of the remote cholinergic neuronal loss in the caudate putamen30:28
Altered EEG microstructure of hippocampal NREM sleep as the earliest and long-lasting30:34
NREM sleep EEG microstructure 91 days after the PPT lesion30:43
High voltage sleep spindles during REM - 130:48
High voltage sleep spindles during REM - 231:14
c-Fos immunostaining in hippocampus31:38
Delayed hypoactivity31:50
Acknowledgments32:07
University of Belgrade32:30
Today the Institute employs 275 researchers - 193 PhDs and 82 PhD candidates.32:36