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Tailoring biomolecular interactions of core-shell nanoparticles and their application to magnetoresponsive drug delivery vehicles
Published on Jul 09, 2018426 Views
Core-shell nanoparticles can be used in biomedical applications, e.g., as biomedical imaging contrast agents, for hyperthermia and in drug delivery, as well as for biotechnological applications such a
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Tailoring biomolecular interactions of core-shell nanoparticles and their application to magnetoresponsive drug delivery vehicles00:00
Outline00:07
Core-shell nanoparticle design and interactions00:55
Anatomy of core-shell nanoparticles01:10
Monodisperse superparamagnetic core-shell NP synthesis02:23
SPION stabilization with anchored dispersants - 104:10
SPION stabilization with anchored dispersants - 206:11
Control over shell thickness and NP stability06:28
Properties as contrast agents08:06
SPION cell uptake and cytotoxicity09:51
Magnetothermal colloidal stability and extraction control10:53
Polymer brush topology – cyclic polymers - 112:11
Polymer brush topology – cyclic polymers - 213:25
Polymer brush topology – cyclic polymers - 314:23
Size-dependent „specific“ binding - 115:01
Size-dependent „specific“ binding - 216:22
Size-dependent „specific“ binding - 317:32
Magnetically controlled drug delivery vesicles18:32
Liposome drug delivery systems - 118:39
Liposome drug delivery systems - 219:02
Magnetically triggered release from liposomes - 120:03
Magnetically triggered release from liposomes - 220:27
Monodisperse hydropbobic core-shell SPIONs in the membrane20:48
Nitrocatechol-palmityl coated particles incorporated in liposomes21:16
Magnetically triggered release from liposomes - 121:31
Magnetically triggered release from liposomes - 222:05
Magnetically triggered release from liposomes - 322:59
Summary23:57
Acknowledgments25:22