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mRNA sequence determinants of protein production rate
Published on 2018-07-09475 Views
Protein synthesis is of paramount importance to every living cell. The major challenge in molecular biology is to understand how information that is encoded in an mRNA transcript affects the rate of m
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Presentation
Messenger RNA sequence determinants of protein production rate00:00
Introduction - 100:36
Introduction - 200:51
Introduction - 300:59
Introduction - 401:46
Codon (usage) bias02:25
Translational efficiency06:05
Can physics help?09:43
Biophysical modelling10:07
Kinetic rates11:20
Mathematical complications - 112:21
Mathematical complications - 213:12
Parameter estimation for yeast (5836 genes)13:36
Series expansion in α15:49
Comparison with numerical simulations16:42
Conclusions19:57
Collaborators21:26