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Cancer Risk and the Somatic Cell-lineage Tree
Published on Jul 09, 2018398 Views
All the cells of an organism are the product of cell divisions organized into a single binary tree. This somatic cell-lineage tree is not uniform in the sense that its lineages have different lengths.
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Chapter list
Cancer Risk and the Somatic Cell-lineage Tree00:00
Somatic Evolution00:39
Cancer Arises from DNA Mutations in Cells03:04
Cancer Development - 103:57
Cancer Development - 204:51
Epidemiological data05:16
Question: How does the cancer incidence depend on the details of the cell-lineage tree? 06:12
Cell-lineage tree of the developing C. elegans07:08
The napoleon oak (a 234-year-old tree)08:44
What is the probability that a lineage (path) with 𝑚 (driver) mutations appear?09:37
Non-renewing tissues: divisions along a perfect binary tree gives the theoretical minimum number of divisions12:34
Renewing tissues: hierarchical tissue organization - 114:38
Renewing tissues: hierarchical tissue organization - 217:11
Hematopoiesis17:44
Microscopic events in the optimal tissue dynamics - 118:31
Microscopic events in the optimal tissue dynamics - 220:49
Average length of the longest cell-lineage20:54
Optimal hierarchy22:44
Conclusion24:22