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Cell biomechanics as a marker of disease development: the case of calcific aortic valve disease
Published on Jul 09, 2018474 Views
Cells sense forces from the extracellular matrix (ECM) and transduce them into biochemical signals. The molecules produced cause in turn remodeling of the ECM. Molecular altered expression will affect
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Cell Biomechanics as a marker of disease development: the case of calcific aortic valve disease00:00
www.elettra.eu00:12
NanoInnovation Lab Projects Overview00:27
An Atomic Force Microscopy Lab01:37
DNA-barcoded Nanoarrays02:46
ECD-Her2 detection03:52
Multiplexing Assay05:01
Strategies for personalized medicine05:25
Cell Biomechanics07:05
Mechanobiology07:10
How to study cell mechanics08:53
AFM Force-Spectroscopy - 109:38
AFM Force-Spectroscopy - 210:32
Calcific aortic valve disease13:23
Calcific Aortic Valve Disease (CAVD)13:25
Aortic Valve Interstitial Cells (VICs) on Polyacrylamide gels15:51
Cellular rigidity is determined by the rearrangement of the cytoskeleton 16:45
Rearrangement of the Cytoskeleton and cell stiffness18:42
High cytoskeleton tensioning determines high levels of YAP nuclear localization19:36
Ex-vivo tissue: stiffness of human aortic valve leaflet20:04
ECM morphology contribution to Calcific Aortic Valve Disease: the carbon nanotubes matrix21:55
CVD growth 2D CNTs substrates* - 122:23
CVD growth 2D CNTs substrates* - 223:13
Raman and XPS characterization24:01
Patterned CVD grown CNTs - 124:20
Patterned CVD grown CNTs - 225:10
t-CNTs influences cell morphology25:26
t-CNTs influences VICs stiffness26:06
t-CNTs influences Focal Adhesions26:55
CNTs-membrane interaction - 127:23
CNTs-membrane interaction - 227:56
Conclusions28:15