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Retrotranspozoni: "trojanski konji" naših genov
Published on Mar 21, 202365 Views
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Retrotranspozoni: 'Trojanski konji' naših genov00:00
If DNA is a cookbook, RNAs are the recipes01:01
Each gene is first dutifully transcribed into a nascent RNA - 104:01
Each gene is first dutifully transcribed into a nascent RNA - 204:17
Only exons are used to make the final recipe, the ’mRNA’04:19
Most genes can produce variant mRNA recipes04:42
Only a tiny part of human genome makes the mRNA recipes!05:25
P53: a protein protecting us from cancer07:26
P53 gene in the human genome10:02
Barbara McClintock13:11
Barbara McClintock13:43
Retrotransposons are a common source of repetitive sequences 14:47
Alus are primate-specific retrotransposons16:50
Alu elements in the human genome18:55
Many thousands of Alus contain sequences that can make exons19:17
Lee et al, ‘An improved iCLIP protocol’, bioRxiv 202122:17
hnRNP C displaces U2AF65 from introns - 123:42
hnRNP C displaces U2AF65 from introns - 224:37
Alu elements are a source of new exons in primate25:47
We discovered a protein that masks the Alu-exons27:11
Mutations can shorten U-tracts to unmask the Alu-exons27:28
A mutation in the hnRNP C binding site leads to neurologic disease28:32
With additional mutations, beneficial Alu-exons can evolve 29:22
Genome is full of instructions for new RNA recipes that are masked30:39
Klara Kuret32:06
https://imaps.goodwright.com/apps/peka32:49
Protein-RNA complexes33:48
Integrate layers of data - 137:33
Integrate layers of data - 239:07
ljubljana Lab39:34
Thank you40:01