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Automating Biology Using Robot Scientists
Published on Aug 17, 20125654 Views
A robot scientist is a physically implemented robotic system that applies techniques from artificial intelligence to execute cycles of automated scientific experimentation. A Robot Scientist can autom
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Chapter list
Automating Biology Using Robot Scientists00:00
The Concept of a Robot Scientist00:11
Talk Plan01:33
Motivation: Philosophical02:09
Richard Feynman’s Blackboard02:55
Motivation 2: Technological - 103:14
Motivation 2: Technological - 204:09
The Complexity of Biological Systems06:00
Motivation 3: AI - 107:01
aaaMotivation 3: AI - 209:17
Scientific Discovery10:54
Meta-Dendral11:12
Bacon13:06
Into the Lab13:52
Robot Scientist Timeline14:02
Pictures of Adam14:26
The Application Domain15:56
Formalising the Problem18:02
The Experimental Cycle - 118:18
Model v Real-World18:23
Logical Cell Model18:56
Phenyalanine, Tyrosine, and Tryptophan - 119:58
Genome Scale Model of Yeast Metabolism20:30
The Experimental Cycle - 220:57
Inferring Hypotheses21:01
Automated Model Completion22:11
Phenyalanine, Tyrosine, and Tryptophan - 222:49
The Experimental Cycle - 323:08
The Form of the Experiments23:09
Phenyalanine, Tyrosine, and Tryptophan - 323:45
Inferring Experiments24:42
Active Learning25:11
The Experimental Cycle - 425:56
Adam26:00
Diagram of Adam26:23
Adam in Action - 126:34
Adam in Action - 226:36
Growth plates30:56
Example Growth Curves31:04
Growth curves31:10
The Experimental Cycle - 531:40
Qualitative to Quantitative31:42
The Experimental Cycle - 532:06
Closing the Loop32:08
Discovery of Novel Science32:15
Novel Science32:18
Novel Scientific Knowledge32:50
Eve32:56
Pictures of Eve33:00
Parasitic Diseases targeted33:13
Enzymes Targeted34:22
Formalising the Problem34:30
Design34:51
Synthetic Biology based Assays35:33
Eve’s Hardware36:47
Eve’s Intelligent Screening37:21
The Economics of Intelligent Screening38:04
Table of Results38:42
Eve hits38:55
Planned Extensions39:16
Formalising Science39:40
Formalisation of Science39:48
Robot Scientist & Formalisation40:24
Adam’s Investigations40:44
Investigation graph41:35
Levels in the Formalisation42:08
automated study of yer152c function42:39
The Future?42:48
Vision43:40
In a 100 years?44:26
Conclusions45:07
Acknowledgments45:38