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Chemistry and biology of aging and age-related diseases
Published on 2017-12-09755 Views
Proteins carry on, directly or indirectly, all life activities and are subject to oxidative damage. Ever since the increase in atmospheric oxygen from about 1 to 21%, accompanied by the shift from ana
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Presentation
MedILS00:00
Future Mediterranean Institute for Life Sciences in 200306:16
Picture07:06
Picture - 107:17
Picture - 207:30
Picture - 307:58
Picture - 408:31
Picture - 508:37
Biology of aging and age-related diseases08:43
All things are difficult before they are easy13:14
Delaying destiny13:44
Delaying destiny - 115:20
Ros15:52
Ros, protein damage and its impact16:02
Mutator phenotype of chaperone deletions depends on high oxidative damage to misfolded proteins21:14
Sketched « Krisko Plots »24:18
Cellular functional degeneracy, aging and death by proteome oxidation26:22
Performance of genetically identical individuals, of the same age, in an identical environment27:17
Aging and diseases are reversible28:09
Accelerated ageing correlates with accelerated carbonylation29:32
A small fraction of human proteins are oxidable – most are “inox”!30:08
The Causes of Protein Carbonylation31:22
Competitive Antagonism between Folding and Oxidation33:23
Fixed protein errors - example35:00
"Silent"polymorphims at young age becomes "loud" at old age36:05
Inborn syndromes37:37
Cellular parabiosis, cancer latency and tumour promotion38:17
Revealing latent recessive phenotypes38:54
Specific Metabolic rate vs. Body mass40:21