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Large data analysis of genetic and imaging data
Published on Nov 28, 20161615 Views
In recent years neuroeconomic analysis of economic and strategic behavior has provided insights into the biological pathways affecting this behavior, and insights into the individual differences (fo
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Chapter list
Large data analysis of genetic and imaging data00:00
Aims of this talk00:01
Imaging data00:45
Representative fMRI study: Design - 100:45
Representative fMRI study: Design - 200:57
Choice of late payment option - 101:43
Choice of late payment option - 203:56
Normalized BOLD path in a vmPFC voxel and values of offers06:21
Data size for the choice task08:54
Decaying BOLD activity during delay10:33
Parametric modulation of BOLD in SPL11:31
Memory and Choice 12:20
Working memory performance and choice14:29
Genetic Data16:48
Genotype for each subject17:01
Two SNP's17:50
GWAS and PRS - 123:41
Gwas-betas from training sample - 124:58
Gwas-betas from training sample - 225:09
PRS25:31
Distribution of standarized PRS27:09
PRS and College - 127:48
PRS and College - 234:36
So what?34:40
Competing explanations34:47
What are Pathways from traits to Educational Outcomes?36:22
Education years of twins, OLS: possible pathways36:52
Education years of twins, OLS: conditioning on PRS of parents38:22
What are Pahthways from PRS to traits? - 139:57
What are Pahthways from PRS to traits? - 240:09
What are Pahthways from PRS to traits? - 340:34
Statistical Analysis40:40
Gene Set Enrichment Analysis41:20
Example of biological pathways42:21
Idea of GSEA - 143:25
Idea of GSEA - 244:37