Towards 3D modeling of Interacting TM Helix Pairs Based on Classification of Helix Pair Sequence
published: Oct. 14, 2010, recorded: September 2010, views: 2568
Report a problem or upload filesIf you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Spatial structures of transmembrane proteins are difficult to obtain either experimentally or by computational methods. Recognition of helix-helix contacts conformations, which provide structural skeleton of many transmembrane proteins, is essential in the modeling. Majority of helix-helix interactions in transmembrane proteins can be accurately clustered into a few classes on the basis of their 3D shape. We propose a Stochastic Context Free Grammars framework, combined with evolutionary algorithm, to represent sequence level features of these classes. The descriptors were tested using independent test sets and typically achieved the areas under ROC curves 0.60-0.70; some reached 0.77.
Link this pageWould you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !