Predicting co-evolving pairs in Pfam using information theory where entropy is determined by phylogenetic mutation events

author: Scooter Willis, University of Florida
published: Feb. 25, 2007,   recorded: June 2006,   views: 3320

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The accurate prediction of co-evolving pairs in protein sequences plays an important role in tertiary protein structure prediction and protein engineering. Using information theory to detect co-evolving pairs is impacted by the phylogenetic effect on entropy measurements. Mutual Information (MI) is used to detect co-evolving pairs in a protein family by re-sampling based on mutation events in the phylogenetic tree (RPE).

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