Candidate gene prioritization by genomic data fusion

author: Yves Moreau, Department of Electrical Engineering, KU Leuven
published: Nov. 20, 2007,   recorded: September 2007,   views: 421453
Categories

Slides

Related Open Educational Resources

Related content

Report a problem or upload files

If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Lecture popularity: You need to login to cast your vote.
  Bibliography

Description

The overwhelming amount of biological data makes the assignment of candidate genes to diseases and biological pathways a formidable challenge. We present ENDEAVOUR, a generally applicable computational methodology to prioritize candidate genes based on their similarity to case-specific reference gene sets. Unlike previous methods, ENDEAVOUR is capable of flexibly utilizing multiple data sets from diverse sources. It allows the modular incorporation of de novo generated data sets and integrates distinct prioritizations into a global ranking by applying order statistics. We first validate the overallperformance in a statistical cross validation of 29 diseases and 3 biological pathways. We validate a novel candidate for DiGeorge syndrome in a zebrafish model and present several new candidates for congenital heart disease. We extend the basic ENDEAVOUR methodology using data from multiple species (human, mouse, rat, drosophila and C. elegans). We also present an alternative machine learning methodology for gene prioritization using kernel methods for novelty detection that outperforms our previous results.

See Also:

Download slides icon Download slides: mlsb07_moreau_cgp.pdf (8.3 MB)

Download slides icon Download slides: mlsb07_moreau_cgp.ppt (21.8 MB)


Help icon Streaming Video Help

Link this page

Would you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !

Reviews and comments:

Comment1 Mathew Hyden, November 18, 2021 at 10:10 a.m.:

A wonderful lecture was delivered by Yves Moreau on one of the most complex topics in biology. One of my friends asked me to visit this website to watch the entire lecture repeatedly when I wasn't feeling well during my college lecture. Now I will visit https://edubirdie.net/blog/edubirdie-... website to read people's feedback about essay writers before hiring them to assist me in my essay that I would like to write on this topic.


Comment2 almahmoud84 .., March 8, 2022 at 8:57 a.m.:

thank you sir for this lacture , I learn more things from you

Write your own review or comment:

make sure you have javascript enabled or clear this field: