About
Within the context of Systems Biology there is a growing requirement for the development of mechanistic models to support reasoning about the structures of biochemical pathways. In addition to defining such models, a means of objectively assessing the validity of competing hypotheses regarding pathway structures based on experimental data and prior knowledge is essential. As the models themselves will have been identified from experimental observations for which there is significant variability it is advisable to adopt a consistent grammar for scientific reasoning that will take account of this uncertainty.
The Bayesian perspective is highly appropriate to enable consistent reasoning over mechanistic models of biological systems. However, given the intractable nature of the integrals required for an analytical Bayesian solution we are required to turn to Markov chain Monte Carlo or other approximating techniques to perform system identification and model-based reasoning. Practical solutions to these problems are critical to the utility and realism of systems biology models.
The goal of this workshop explores the main methodological and technical issues associated with performing Bayesian inference over mechanistic biochemical pathway models. It brings together experts in systems biology, statistical inference and machine learning (through the PASCAL networks).
For more information visit the Workshop website.
Videos

Mathematical Modeling of Cell Signalling Pathways
Nov 6, 2007
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12142 views
A software tool for Bayesian inference of ODE Biochemical Models
Nov 6, 2007
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3721 views
A study of MCMC and deterministic approximations for hypothesis testing using OD...
Nov 6, 2007
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3421 views

Weak noise approximate inference for diffusion models
Nov 6, 2007
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3203 views
Reconstructing hidden protein activity by nonparameteric methods
Nov 6, 2007
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3076 views

Towards a Polymer Model of Genetic Recombination
Nov 6, 2007
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3688 views
Parameter estimation of ODE's using Support Vector Regression and Qualitative Co...
Nov 6, 2007
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5786 views

From Physiologically Based Pharmacokinetic Modelling toward System Biology
Nov 6, 2007
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6612 views

Variational Inference for Markov Jump Processes
Nov 6, 2007
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5904 views

Gene regulatory network reconstruction by Bayesian integration of prior knowledg...
Nov 6, 2007
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9336 views

Bayesian Inference of Mechanistic Systems Models Using Population MCMC
Nov 6, 2007
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6060 views