Workshop on Practical Inference Methods for Mechanistic Modelling of Biological Systems (PIMMS), Glasgow 2007

Workshop on Practical Inference Methods for Mechanistic Modelling of Biological Systems (PIMMS), Glasgow 2007

11 Videos · Sep 18, 2007

About

Within the context of Systems Biology there is a growing requirement for the development of mechanistic models to support reasoning about the structures of biochemical pathways. In addition to defining such models, a means of objectively assessing the validity of competing hypotheses regarding pathway structures based on experimental data and prior knowledge is essential. As the models themselves will have been identified from experimental observations for which there is significant variability it is advisable to adopt a consistent grammar for scientific reasoning that will take account of this uncertainty.

The Bayesian perspective is highly appropriate to enable consistent reasoning over mechanistic models of biological systems. However, given the intractable nature of the integrals required for an analytical Bayesian solution we are required to turn to Markov chain Monte Carlo or other approximating techniques to perform system identification and model-based reasoning. Practical solutions to these problems are critical to the utility and realism of systems biology models.

The goal of this workshop explores the main methodological and technical issues associated with performing Bayesian inference over mechanistic biochemical pathway models. It brings together experts in systems biology, statistical inference and machine learning (through the PASCAL networks).

For more information visit the Workshop website.

Videos

video-img
37:05

Mathematical Modeling of Cell Signalling Pathways

Julio Vera González

Nov 6, 2007

 · 

12142 views

video-img

A software tool for Bayesian inference of ODE Biochemical Models

Vladislav Vyshemirsky

Nov 6, 2007

 · 

3721 views

video-img

A study of MCMC and deterministic approximations for hypothesis testing using OD...

Vladislav Vyshemirsky

Nov 6, 2007

 · 

3421 views

video-img
21:25

Weak noise approximate inference for diffusion models

Andreas Ruttor

Nov 6, 2007

 · 

3203 views

video-img

Reconstructing hidden protein activity by nonparameteric methods

Lorenz Wernisch

Nov 6, 2007

 · 

3076 views

video-img
15:22

Towards a Polymer Model of Genetic Recombination

Christopher Penfold

Nov 6, 2007

 · 

3688 views

video-img

Parameter estimation of ODE's using Support Vector Regression and Qualitative Co...

Paola Bouchet

Nov 6, 2007

 · 

5786 views

video-img
23:16

From Physiologically Based Pharmacokinetic Modelling toward System Biology

Frédéric Y. Bois

Nov 6, 2007

 · 

6612 views

video-img
25:50

Variational Inference for Markov Jump Processes

Guido Sanguinetti

Nov 6, 2007

 · 

5904 views

video-img
39:41

Gene regulatory network reconstruction by Bayesian integration of prior knowledg...

Dirk Husmeier

Nov 6, 2007

 · 

9336 views

video-img
28:33

Bayesian Inference of Mechanistic Systems Models Using Population MCMC

Ben Calderhead

Nov 6, 2007

 · 

6060 views