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Learning mechanisms of drug dependence
Published on Sep 07, 20151628 Views
The development of drug dependence relies heavily on an aberrant learning history. Initially, the experience of the drug itself is linked with environmental cues through a process of Pavlovian conditi
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Chapter list
Learning mechanisms of drug dependence00:00
In this talk…00:57
Stages in drug addiction - 102:09
Development of a drug-seeking habit?02:58
Caudate putamen dopamine evoked by cocaine cues03:22
Stages in drug addiction - 203:54
Cocaine Self Administration in Rats04:40
Assignment of Incentive Salience - 106:38
Assignment of Incentive Salience - 207:50
A learning mechanisms involved in drug seeking08:25
The other dopamine pathway09:44
Working neurological model10:22
Circuitry recruitment10:45
Blocking DA receptors in the dorsal striatum - 111:04
Blocking DA receptors in the dorsal striatum - 211:47
Instrumental learning in addiction12:45
Prolonged training and the development of a S-R habit13:32
Cocaine seeking-taking chained schedule - 114:36
Cocaine seeking-taking chained schedule - 215:32
Conditioned Stimuli – Conditioned Reinforcers - 116:37
Conditioned Stimuli – Conditioned Reinforcers - 217:29
Needle Freaks17:39
Cue-exposure therapy - 118:45
Cue-exposure therapy - 219:05
Urge to use19:17
Extinction - 119:34
Extinction - 219:53
Extinction - 320:11
Cue-exposure therapy20:31
Threats to extinction22:02
Cue-exposure therapy - 323:27
Drug is more than reward or reinforcer24:16
Drug states as stimuli - 124:41
Drug states as stimuli - 224:49
Drug states as stimuli - 324:53
Drug can serve as an interoceptive CS25:01
Pavlovian Drug Discrimination - 125:10
Measure25:26
Pavlovian Drug Discrimination - 226:19
Nicotine Conditioned Stimulus26:48
Drug can act like an exteroceptive CS27:18
Compound Acquisition - 128:46
Compound Acquisition - 229:02
Element Testing29:07
Cue-exposure therapy - 430:05
Alcohol exposure therapy - 131:11
Alcohol exposure therapy - 232:00
Pharmacokinetic contributions - 132:48
Pharmacokinetic contributions - 234:04
Extinction - 434:50
In summary35:26
Acknowledgements36:01