Part 2: A Novel Bayesian Approach for Uncovering Potential Spectroscopic Counterparts for Clinical Variables in 1H NMR Metabonomic Applications

coauthor: Mika Ala-Korpela, Lappeenranta University of Technology
author: Ville-Petteri Mäkinen, Aalto University
published: April 15, 2007,   recorded: June 2006,   views: 4486
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Description

Metabonomic approaches based on spectroscopic data are in their infancy in biomedicine. A key challenge in clinical metabonomics is uncovering and understanding the relations between the multidimensional spectroscopic data and the clinical measures currently used for disease risk assessment and diagnostics. A novel Bayesian approach for revealing clinically relevant signals is presented here for a real 1H NMR metabonomics data set. The results are not only mathematically superior but also biochemically fully coherent.

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