From Physiologically Based Pharmacokinetic Modelling toward System Biology
published: Nov. 6, 2007, recorded: September 2007, views: 6594
Report a problem or upload filesIf you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Pharmacokinetic (PK) modelling has had since the beginning a systemic approach to the description of chemicals absorption, distribution, metabolism and excretion in or from the body. The earliest PK models were physiological and mechanistic in the sense that they started from a mathematical description of the body as organs of given composition and properties, linked by blood flow. For a while, the lack of fast methods for solving differential equation systems led to the formulation and use of empirical and much simpler compartmental models. Interest in physiologically based (PBPK) modelling has persisted, however, in toxicology where data are sparse, and where transpositions from animals to humans are best grounded in physiology and biochemistry. Advances in Bayesian numerical analysis now allow rigorous inferences for PBPK models, including in the context of complex data structures (e.g., hierarchical or "population" models).
Download slides: pim07_bois_fpb_01.pdf (324.3 KB)
Download slides: pim07_bois_fpb_01.ppt (1.4 MB)
Link this pageWould you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !