Fascinantne štiriverižne strukture DNK v človeških papilomavirusih

author: Janez Plavec, Kemijski inštitut Ljubljana
published: Dec. 23, 2016,   recorded: December 2016,   views: 27
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DeoksiriboNukleinska Kislina (DNK) je nosilka dednih informacij. Vsebuje gene, ki kodirajo zapis za proteine in dele z nadzornimi vlogami. V celici je najpogosteje v obliki dvojne vijačnice. Z gvanini bogata zaporedja pa se v prisotnosti kationov zvijejo v alternativne štirivijačne sekundarne strukture DNK - G-kvadruplekse. Le-ti se lahko tvorijo v telomernih zaporedjih, v regulatornih območjih pa tudi v genomih virusov. Človeški papilomavirusi (HPV) so patogeni, ki povzročajo raka glave in vratu, kože ter anogenitalnih predelov. V genomih nekaterih tipov HPV smo našli predele s potencialom za tvorbo Gkvadrupleksov, ki bi lahko služili kot tarče za nadzor prepisovanja in podvajanja HPV.

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