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Inferring a measure of physiological age from multiple ageing related phenotypes
Published on 2012-01-234033 Views
What is ageing? One definition is simultaneous degradation of multiple organ systems. Can an individual be said to be “old” or “young” for their (chronological) age in a scientifically meaningful way?
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Presentation
Inferring a measure of physiological age from multiple ageing related phenotypes00:00
Motivation (part 1)00:29
Motivation (part 2)01:57
Setting the scene03:16
Global systemic ageing04:40
Linear model05:51
This 55 year old individual has the nuclear dip of a 67 year old07:40
The same 55 year old individual has the telomeres of a 72 year old09:06
Delta vs. age - 109:37
Non-linear model - 110:59
Non-linear model - 211:45
Delta vs. age - 212:14
Delta vs. age - 313:16
Held out phenotype test13:26
Bayes factors15:54
Genes correlated with ageing16:40
Conclusions (part 1)18:37
Ongoing work19:32
Conclusions (part 2)21:16