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Machine Learning in Systems Biology
Pascal

Towards a semi-automatic functional annotation tool based on decision tree techniques

coauthor: Jean-François Gibrat, INRA - Paris
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Slides
0:00 - Towards a semi-automatic functional annotation tool based on decision tree techniques - Announcement
0:05 Towards a semi-automatic functional annotation tool based on decision tree techniques
0:26 Context
0:31 Annotation : from raw data to knowledge
1:59 Annotation platform AGMIAL
3:05 Atlas view of the lactobacillus sakei genom
3:36 Pareo
3:54 Annotation platform AGMIAL
3:58 In summary - 1
4:12 In summary - 2
4:29 In summary - 3
4:33 In summary - 4
4:39 In summary - 5
5:18 Project motivation
5:22 Goal - 1
5:28 Goal - 2
5:32 Goal - 3
6:01 Goal - 4
6:14 Goal - 5
6:23 Goal - 6
6:33 Data
6:36 Genomes - 1
6:51 Genomes - 2
7:49 Subtilist functional hierarchy - 1
8:32 Subtilist functional hierarchy - 2
8:39 Subtilist functional hierarchy - 3
8:55 Genomes - 2
9:06 Genomes - 3
9:44 Annotation in a nutshell
10:43 Annotation rules
12:29 Machine learning techniques
12:33 Problem to be solved
12:40 Inductive logic programming framework Tilde
14:03 Relational data } attribute-value data
15:14 Multilabel probabilistic decision-tree
15:49 Evaluation measures
15:53 Hierarchical evaluation measures
16:48 Hierarchical evaluation measures - Example
17:46 Hierarchical evaluation measures
18:13 Results
18:16 Prediction parameters
19:07 Influence of threshold on hierarchical precision
19:20 Influence of threshold on hierarchical recall
19:30 Influence of threshold on hierarchical F score
19:47 Prediction parameters
19:49 Results for a 75% threshold
20:55 Multilabel probabilistic decision tree
21:06 TILDE decision trees
21:08 Example of rule : protein 1739 of L sakei - 1
22:39 Example of rule : protein 1739 of L sakei - 2
22:52 Example of rule : protein 1739 of L sakei - 3
23:00 Example of rule : protein 1739 of L sakei - 4
23:06 Perspectives
23:10 Conclusions – perspectives
25:15 - Questions
25:43 - Questions
26:01 - Questions
27:04 - Questions

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