Predicting Binding Affinities of MHC Class II Epitopes Across Alleles

author:Nico Pfeifer, University of Tübingen
published: Dec. 20, 2008,   recorded: December 2008,   views: 89
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Slides

Slides
0:00 MHCII
0:38 What makes the problems difficult? - 1
1:05 What makes the problems difficult? - 2
1:30 Related work - 1
1:59 Related work - 2
2:07 Roadmap: Methods
2:13 Peptide-MHCII binding affinity prediction - 1
2:27 Peptide-MHCII binding affinity prediction - 2
2:37 Peptide-MHCII binding affinity prediction - 3
3:03 Peptide-MHCII binding affinity prediction - 4
3:22 Peptide-MHCII binding affinity prediction - 5
3:37 - Questions
5:18 Multiple instance learning - 1
5:33 Multiple instance learning - 2
6:21 Multiple instance learning - 3
6:39 Normalized set kernel
7:25 Single predictor - 1
7:34 Single predictor - 2
7:47 Single predictor - 3
8:04 MHCIImulti - 1
8:22 MHCIImulti - 2
8:25 MHCIImulti - 3
8:48 MHCIImulti - 4
9:00 MHCIImulti - 5
9:10 MHCIImulti - 6
9:11 MHCIImulti - 7
9:12 MHCIImulti - 8
9:13 MHCIImulti - 9
9:14 MHCIImulti - 10
9:15 MHCIImulti - 11
9:16 MHCIImulti - 12
9:17 MHCIImulti - 13
9:27 Virtual matrices
9:37 Covering more alleles - 1
9:39 Covering more alleles - 2
10:00 Covering more alleles - 3
10:08 Covering more alleles - 4
10:29 Multitask learning - 1
11:05 Multitask learning - 2
11:14 Positionally-weighted RBF kernel - 1
11:54 Positionally-weighted RBF kernel - 2
12:06 Positionally-weighted RBF kernel - 3
12:29 Predictor which uses data from multiple alleles - 1
12:40 Predictor which uses data from multiple alleles - 2
12:45 Predictor which uses data from multiple alleles - 3
12:53 Roadmap: Results
12:56 Benchmark - 1
13:09 Benchmark - 2
13:19 Benchmark - 3
13:58 Benchmark - 4
14:02 Comparison - 1
14:59 Comparison - 2
15:14 Leave-One-Allele-Out (LOAO) prediction - 1
16:22 Leave-One-Allele-Out (LOAO) prediction - 2
16:51 Leave-One-Allele-Out (LOAO) prediction - 3
17:12 Comparison - 3
17:31 Summary - 1
17:44 Summary - 2
17:52 Summary - 3
18:02 Summary - 4
18:12 Thanks
18:56 - Questions

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