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Some physics of viruses and the grand questions still unanswered
Published on 2013-03-114334 Views
Seventy years after Schrödinger asked „What is life?“ we know that life is something related to information. But how „non-living“ matter became imbued with information is even a toughest question than
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Presentation
Some physics of viruses and the grand questions still unanswered00:00
Virus 03:01
Turnip yellow mosaic virus 04:36
Hepatitis B virus05:35
Tobacco ringspot virus05:50
Echovirus06:00
Nodamura virus06:11
Geodesic dome - 106:21
Geodesic dome - 207:26
Structure of the virus07:56
Complicated structures09:28
Caspar-Klug quasiequivalence principle10:03
Caspar-Klug classification of icosahedral viruses10:24
Number of protein subunits12:08
There is something optimal about these things13:26
Tents13:38
Same structure14:03
Gigantic icosahedral fullerenes - 114:14
Gigantic icosahedral fullerenes - 214:29
Gigantic icosahedral fullerenes - 315:17
Gigantic icosahedral fullerenes - 415:34
HOW do they look like, and WHY do they look like that?16:00
Capsid radius16:18
Capsid thickness18:24
Viruses as elastic entities19:43
Small viruses and large viruses20:16
Stretching and bending20:54
Unique functions21:56
FvK number24:32
best fit FvK shape25:05
Real virus and FvK fit26:28
Ratio26:40
What does it mean? Are all viruses related?27:47
Viruses as electrostatic entities28:07
Interactions28:34
Proteins29:24
Experiment - 129:54
Experiment - 230:44
Which one will form and why?31:58
Role of electrostatic interactions32:24
Experiment - 332:45
Hydrophobic attraction34:01
What does it mean? „Design” of protein interactions in viruses.34:08
Reconstitution of active tobacco mosaic 34:28
Measurements - 135:29
Model - 135:52
Model - 236:43
Model - 337:27
Cucumber mosaic virus capsid38:36
PCCP39:00
Flexible capsid protein tails39:27
Very diffiicult to „salti out” the „RNA”39:31
Reproducing40:31
Measurements - 240:46
Electrostatic origin of the genome packing in viruses40:56
What does it mean? Electrostatic evolutionary „design” of capsid proteins?41:41
Specific charge - 141:58
Specific charge - 243:07
Specific charge - 343:48
Specific charge - 444:07
(Non)specificity?44:50
What does it mean?45:07
Thank you for your attention !45:29