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Some physics of viruses and the grand questions still unanswered
Published on Mar 11, 20134328 Views
Seventy years after Schrödinger asked „What is life?“ we know that life is something related to information. But how „non-living“ matter became imbued with information is even a toughest question than
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Some physics of viruses and the grand questions still unanswered00:00
Virus 03:01
Turnip yellow mosaic virus 04:36
Hepatitis B virus05:35
Tobacco ringspot virus05:50
Echovirus06:00
Nodamura virus06:11
Geodesic dome - 106:21
Geodesic dome - 207:26
Structure of the virus07:56
Complicated structures09:28
Caspar-Klug quasiequivalence principle10:03
Caspar-Klug classification of icosahedral viruses10:24
Number of protein subunits12:08
There is something optimal about these things13:26
Tents13:38
Same structure14:03
Gigantic icosahedral fullerenes - 114:14
Gigantic icosahedral fullerenes - 214:29
Gigantic icosahedral fullerenes - 315:17
Gigantic icosahedral fullerenes - 415:34
HOW do they look like, and WHY do they look like that?16:00
Capsid radius16:18
Capsid thickness18:24
What does it mean? Are all viruses related?19:05
Viruses as elastic entities19:43
Small viruses and large viruses20:16
Stretching and bending20:54
Unique functions21:56
FvK number24:32
best fit FvK shape25:05
Real virus and FvK fit26:28
Ratio26:40
What does it mean? Are all viruses related?27:47
Viruses as electrostatic entities28:07
Interactions28:34
Proteins29:24
Experiment - 129:54
Experiment - 230:44
Which one will form and why?31:58
Role of electrostatic interactions32:24
Experiment - 332:45
Hydrophobic attraction34:01
What does it mean? „Design” of protein interactions in viruses.34:08
Reconstitution of active tobacco mosaic 34:28
Measurements - 135:29
Model - 135:52
Model - 236:43
Model - 337:27
Cucumber mosaic virus capsid38:36
PCCP39:00
Flexible capsid protein tails39:27
Very diffiicult to „salti out” the „RNA”39:31
Reproducing40:31
Measurements - 240:46
Electrostatic origin of the genome packing in viruses40:56
What does it mean? Electrostatic evolutionary „design” of capsid proteins?41:41
Specific charge - 141:58
Specific charge - 243:07
Specific charge - 343:48
Specific charge - 444:07
(Non)specificity?44:50
What does it mean?45:07
Thank you for your attention !45:29