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EPSRC Winter School in Mathematics for Data Modelling
Pascal

Modelling Genomic Data

author: Mahesan Niranjan, University of Sheffield

Description

This presentation describes work on the modelling of genomic data.

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Slides
0:00 Analysing Genomic Data
0:46 Classification, Regression & Online Problems
6:02 Sampling Methods: Bayesian Inference
7:03 Importance Sampling
7:07 Particle Filters
8:22 My Research Ambition for the Next Few Years
9:15 Basic Biology: Cell
9:35 Basic Biology: DNA
11:31 Basic Biology: Gene
11:47 Basic Biology: Protein - 1
12:05 Basic Biology: Protein - 2
12:06 Some Further Complexities - 1
13:17 Some Further Complexities - 2
14:36 Two Approaches to Pattern Recognition (Classification)
17:23 Curse of Dimensionality
19:08 Two Approaches to Pattern Recognition (Classification)
20:45 Curse of Dimensionality
20:53 Where CoD Doesn’t Hurt as Much
21:46 Support Vector Machines
21:52 - Nonlinear Kernel Functions
21:56 Classifier Performance - 1
22:42 Classifier Performance - 2
24:04 Classifier Performance - 3
26:52 Convex Hull of ROC Curves
28:23 PARCEL: Feature Subset Selection
29:40 Yeast Gene Classification
36:00 Now for Something Different … - 1
36:08 Basics: Transcriptome and Proteome - 1
38:09 Basics: Transcriptome and Proteome - 2
38:41 Two Views of the Same Dataset
39:15 Regulation
40:57 Data-Driven Models / Machine Learning
42:04 Model "Failure" Can Be Informative I
44:21 Model "Failure" Can Be Informative II
46:23 Data-Driven Models / Machine Learning
46:35 Predictor for Protein Concentrations
49:17 Improvement in Prediction (Small, but Exists)
49:44 - Questions
52:13 Some Encouraging Results?
54:33 - Questions
56:51 Precision: 2.4601 or 2.0?
61:01 Classification
61:34 Clustering - 1
63:50 Clustering - 2
65:12 Clustering - 3
67:09 Periodic Expression: Cell Cycle - 1
67:10 Periodic Expression: Cell Cycle - 2
67:11 Periodic Expression: Cell Cycle - 3
67:17 We May Be Able to Work with Lower Precision…So What?

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