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Live imaging of RNA dynamics for genetic forms of amyotrophic lateral sclerosis (ALS) in zebrafish
Published on Jul 21, 2017887 Views
The recent identification of mutations in TDP-43, FUS, two RNA-binding proteins, altogether with C9orf72 and SOD1 representing more than half of genetic cases, and also SQSTM1 and VCP, seems to un
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Chapter list
Live imaging of RNA dynamics for genetic forms of ALS in zebrafish00:00
The Genetics of ALS - 100:19
The Genetics of ALS - 200:28
The Genetics of ALS - 300:34
The Genetics of ALS - 400:47
TDP-43 and FUS: RNA-binding proteins00:55
Protein and RNA homeostasis01:25
In vivo study of RNA dynamics: the zebrafish model02:43
Genetic interaction between TDP-43 and SQSTM1 - 103:54
Genetic interaction between TDP-43 and SQSTM1 - 204:44
Studying RNA metabolism in ALS05:40
Investigating RNA metabolism: Precise in situ hybridization06:34
In vivo study of RNA dynamics: a modified CRISPR/Cas9 system07:21
The RNA targeting CRISPR/Cas908:57
Future directions10:16
Acknowledgements 11:03