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Hypothalamic atrophy correlates with onset of disease-defining symptoms in patients with ALS
Published on Jul 21, 2017771 Views
Background: Alterations in energy metabolism have been described in the context of ALS but direct evidence of hypothalamic involvement is lacking. The hypothalamus plays a key role in controlling
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Hypothalamic atrophy correlates with onset of disease-defining symptoms in patients with ALS00:00
Energy metabolism in ALS - 100:07
Energy metabolism in ALS - 200:08
Energy metabolism in ALS - 300:45
Objective / Cohorts 01:03
MRI-based segmentation of the hypothalamus - 101:40
MRI-based segmentation of the hypothalamus - 202:00
Data analysis 02:15
Results: Hypothalamic atrophy02:46
Correlations with ALSFRS-R / DTI-Staging 03:17
Correlations with BMI 03:47
Correlations with age at disease onset 04:08
Hypothalamic atrophy prior to disease-defining symptoms? 04:39
Results: Hypothalamic volume in presymptomatic ALS mutation carriers 05:16
Summary 05:32
Team06:47