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Discovery of microRNA gene mutations in ALS patient genomes
Published on Jul 21, 2017792 Views
MicroRNAs, endogenous small RNAs, have been suggested to play a role in many pathologies, including neurodegeneration. We recently demonstrated that Dicer activity is impaired in amyotrophic lateral
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Discovery of microRNA genetic variations in human ALS patients00:00
20 yrs. of human genetics in ALS research00:33
MicroRNAs in ALS - 102:12
MicroRNAs in ALS - 202:56
MicroRNAs in ALS - 303:13
microRNAs Biogenesis04:01
Hypothesis - 105:25
Hypothesis - 205:52
Workflow for Discovery of miRNA-Related Genes Associated With ALS - 106:28
Workflow for Discovery of miRNA-Related Genes Associated With ALS - 206:58
Workflow for Discovery of miRNA-Related Genes Associated With ALS - 307:34
Workflow for Discovery of miRNA-Related Genes Associated With ALS - 407:42
Bioinformatics Assay, Functional Annotation & Statistical test - 107:44
Bioinformatics Assay, Functional Annotation & Statistical test - 208:55
Bioinformatics Assay, Functional Annotation & Statistical test - 309:55
Bioinformatics Assay, Functional Annotation & Statistical test - 410:09
Rare allele association on genes10:19
Preliminary Results Variants in miRNA genes10:38
Motor Neuron Specific miR-21811:46
Preliminary Results Loss of miRNA binding site - 112:20
Preliminary Results Loss of miRNA binding site - 212:43
Summary13:20
Thank you for listening!!13:42