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Secretion of toxic exosomes by muscle cells of ALS patients: role in ALS pathogenesis
Published on Jul 21, 20171114 Views
Background: The causes of ALS remain unknown. For sporadic and familial cases, several studies show an abnormal accumulation of lysosomally-directed protein aggregates in the cytosol. Mutations in
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Secretion of toxic exosomes by muscle cells of ALS patients: role in ALS pathogenesis00:00
Amyotrophic Lateral Sclerosis (ALS)00:08
Dying back00:34
Transcriptomic analysis of ALS muscles - 100:56
Transcriptomic analysis of ALS muscles - 201:59
Sub-sarcolemnal accumulation of MVBs in ALS muscles02:20
Sub-sarcolemnal accumulation of exosomes in ALS muscles02:46
Accumulation of MVBS full of exosome-like vesicle in ALS muscle biopsies02:55
ALS signature in muscle stem cells?03:29
Transcriptomic analysis04:30
We have identified an ALS signature in muscle stem cells04:54
Secretome signature in ALS muscle stem cells05:25
Accumulation of exosomes in myotubes05:38
Increased exosome secretion05:52
ALS exosomes are toxic - 106:47
ALS exosomes are toxic - 208:03
Take home message08:36
ViTAL Consortium08:54
Acknowledgement09:20