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Intraspinal injection of human mesenchymal stromal cells in SOD1G93A ALS mice

Published on Jul 21, 2017936 Views

Introduction: Cellular therapy is being discussed as novel therapeutic option for the treatment of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS). Cell therapy for ALS curre

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Intraspinal injection of human mesenchymal stromal cells in SOD1G93A ALS mice00:00
Cellular therapy00:04
Criteria of the International Society for Cellular Therapy to define MSCs00:45
Isolation of human MSCs01:17
Quality control of MSCs - 101:44
Quality control of MSCs - 202:09
Quality control of MSCs - 302:20
In vitro characterisation of MSCs03:01
In vivo studies of the MSCs03:35
Aims of the in vivo studies03:40
Transgenic ALS mouse model04:02
Intraspinal injection04:10
Behavioural assessments04:41
Intraspinal injection at day 40 - 105:10
Intraspinal injection at day 40 - 205:16
Intraspinal injection at day 40 - 305:38
Intraspinal injection at day 40 - 405:49
Intraspinal injection at day 40 and at day 90 - 105:56
Intraspinal injection at day 40 and at day 90 - 206:03
Intraspinal injection at day 40 and at day 90 - 306:41
Intraspinal injection at day 40 and at day 90 - 406:52
Untitled07:05
Radioactive tracing of MSCs - 207:27
Summary08:03
Outlook08:28
Credits08:50
Thank you for your attention !08:55