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Doctor Jekyll and Mister Hyde: Dual nature of stem cells in cancer
Published on Dec 09, 2017760 Views
Doctor Jekyll and Mister Hyde: Dual nature of stem cells in cancer The existence of stem cells in cancer have already been perceived by Greek physician Hipokrates, but the scientifically based idea
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Chapter list
Dual nature of stem cells in cancer 00:00
Adam and Eve- first human stem cell on Earth was the Source of Good and Evil 00:08
Hypokrates00:18
Normal stem cells in humans take care of (limited) tissue regeneration 00:54
Cancer01:26
Good Dr. Jekyll…01:53
Good Dr. Jekyll - 102:30
As each cell, also the stem cell can be damaged, or the well-differentiated damaged cell can become stem cell02:56
A Paradigm Shift: Asymmetric Division and Hierarchical Order of Cancer Evolution 04:13
Metastases are the Cause of Patients’ Death: Migratory Cancer Stem Cells – CSC 05:15
Glioblastoma06:10
Origin and evolution of GBM stem cells: GSC07:09
Niches: Problem with Glioblastoma Stem Cells Resistance 08:33
Searching for GSC Niches in GBM Sections09:16
GBM Stem cell niches and Proteolytc enzymes-cathepsins 10:18
Cysteine Cathepsins are family of 11 proteolytic enzymes normally located to lyosomes and upregulated in many cancers10:27
Katepsin K and GSC niches11:18
THE VISIONARY MESSAGE – Loosing the battle against evil11:52
Confrontation12:34
DOCTOR JEKYLL becomes MR HYDE cell type? 13:24
MSC – Tropism to Tumours 14:02
Perversion of stem cell potential of pericytes.. MSC become CSC!15:21
Cell Fusion 16:10
GBM invasion17:14
I. invasion17:49
MSCs impaired U87 cells’ but enhanced U373 cells’ invasion upon coinjection into the zebrafish embryos18:37
Summary Protease cascades in MSC- GBM direct contact19:28
Graphic Summary 19:55
Conclusions and comments20:07
Conclusions and comments - 121:06